Photomediated Transformation of Salannin, a Tetranortri- terpenoid from Azadirachta indica A. Juss
نویسنده
چکیده
Photolysis of Salannin (1), an important bioactive compound from Azadirachta indica A.Juss (Neem), affords ∆-isosalanninolide (2), a hitherto unknown compound, along with isosalanninolide (3) and salanninolide (4). A probable mechanism has been suggested. While the mechanism of formation of 2 involves both a [4+2] cycloaddition and a [1,3] sigmatropic shift in the furan and D-rings, respectively, formation of 3 and 4 involves the decomposition of an ozonoide-like peroxide intermediate.
منابع مشابه
An Improved Genome Assembly of Azadirachta indica A. Juss.
Neem (Azadirachta indica A. Juss.), an evergreen tree of the Meliaceae family, is known for its medicinal, cosmetic, pesticidal and insecticidal properties. We had previously sequenced and published the draft genome of a neem plant, using mainly short read sequencing data. In this report, we present an improved genome assembly generated using additional short reads from Illumina and long reads ...
متن کاملSome Pharmacological Actions of ‘nimbidin’- a Bitter Principle of Azadirachta Indica-a Juss (neem)
Nimbidin the major bitter principle from oil of seeds of Azadirachta indica A. Juss was investigated for various pharmacological actions in a number animal models. On central nervous system it exhibited moderate sedative effect it did not show any significant cardiovascular effects in experimental animals. Autonomic pharmacological studies (in-vitro) revealed pronounced anticholinergic antihist...
متن کاملPreparation and Evaluation of tincture of Azadirachta indica A. Juss. Leaves
Different strength of alcohol 40.50,60,70,80,90 per cent (v/v) and absolute were utilized for the preparation of tincture of azadirachta Indica A. Juss leaves by maceration for 7, 14,21 days. 60 per cent tincture produced after 21 says of maceration showed a maximum solid content of 1.425 per cent (v/v) and sowed pH 3.15. This tincture was characterized by studying is various physico-chmicla pr...
متن کاملAzadirachta indica A. juss: Safety and Efficacy during Pregnancy and Lactation
Background: In Nigeria decoctions and aqueous extract of Azadirachta indica A. juss (AI), are commonly used in the treatment of malaria. Some women have been observed consuming aqueous extract of AI during pregnancy and lactation because of the folkloric belief that it is potentially harmless. Objectives: There is a paucity of data on the effects of consumption of AI during pregnancy and lactat...
متن کاملComparative analysis of the terpenoid biosynthesis pathway in Azadirachta indica and Melia azedarach by RNA-seq
Azadirachta indica (neem) is the only source of azadirachtin, which is known for its insecticide activity. Melia azedarach is a related species of A. indica, widely distributed in the south of China. In this study, the leaf transcriptomes of these two Meliaceae plants were sequenced. More than 40 million clean reads were generated from each library. About 80 % of A. indica reads were mapped to ...
متن کامل